Use of fly larva (Maggots) in Cancer Treatment: A systematic review

Introduction: Superficial cancers are one of the most common in humans and animals. The use maggot therapy as an alternative treatment is expanding has achieved great success treating superficial. Maggot extracts secretions have been also demonstrated to beneficial biological effects. present study aimed perform first systematic review maggot, well its extracts, neoplasms. Methods: In current study, online databases, such Pub Med, Web Science, Scopus, Embase, were searched retrieve published studies from 1985-2021. used keywords therapy, Larval extract, secretions, Cancer, Neoplasm, Tumor. Only research on larvae order Diptera was included study. Results: Out 387 screened papers, 9 articles met proposed inclusion criteria. There three debridement tumor lesions six effect extract neoplastic cells. able control complications skin tumors breast cancer. Several reported anti-tumor effects larval secretions. Conclusions: Maggots improve appearance prevent further growth that progressing before therapy. It seems can be treat necrotic tumors; moreover, a wider range Nonetheless, more needed non-progressive determine true this method.